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Updated: Jun 17, 2026

MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease
Published on: February 14, 2012
Direct peptide profiling of brain tissue by MALDI-TOF mass spectrometry
Joachim Schachtner1, Christian Wegener, Susanne Neupert
1Department of Biology, Animal Physiology, Philipps-University, Marburg, Germany.
Abstract:
Direct MALDI-TOF mass spectrometric peptide profiling is increasingly used to analyze the peptide complement in the nervous system of a variety of invertebrate animals from leech to Aplysia and many arthropod species, especially insects and crustaceans. Here, we describe a protocol for direct peptide profiling of defined areas of the central nervous system of insects. With this method, one can routinely and reliably obtain neuropeptide signatures of selected brain areas from various insects.
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