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Rat strain repositories
1Institute of Laboratory Animals, Kyoto University, Kyoto, Japan.
Methods in Molecular Biology (Clifton, N.J.)
|December 17, 2009
Summary
Over 500 inbred rat strains, plus new mutants, are vital for biomedical research. Global resource centers like NBRP-Rat and RRRC manage and distribute these essential rat models.
Area of Science:
- * Animal models in biomedical research
- * Genetics and genomics
- * Laboratory animal science
Background:
- * Over 500 inbred rat strains developed over 100 years for diverse biomedical applications.
- * Recent generation of induced mutants and mutagenized sperm samples expands genetic resources.
- * Two primary global resource centers manage the majority of rat strains: NBRP-Rat (Japan) and RRRC (USA).
Purpose of the Study:
- * To highlight the critical role of rat resource centers in managing and distributing valuable rat models.
- * To emphasize the comprehensive services provided by these centers, including characterization and data management.
- * To underscore the importance of these centers for advancing research utilizing rats as a model species.
Main Methods:
- * Collection, maintenance, and distribution of inbred rat strains, induced mutants, and cryopreserved materials (embryos, spermatozoa).
- * Phenotypic and genetic characterization of rat strains.
- * Microbiological monitoring and cleaning of rat colonies.
- * Development and maintenance of informative databases for strain selection.
Main Results:
- * A vast collection of over 500 inbred rat strains, supplemented by new mutants and genetic materials.
- * Centralized management and distribution by the National Bio Resource Project for the Rat (NBRP-Rat) and the Rat Resource and Research Center (RRRC).
- * Comprehensive support for researchers, including strain information, characterization data, and accessibility.
Conclusions:
- * Global rat resource centers are indispensable for the effective and ongoing use of rats in scientific research.
- * These centers ensure the availability, quality, and appropriate selection of rat models for specific research needs.
- * Continued support and utilization of these resource centers are crucial for future biomedical advancements.
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