Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 17, 2026

Real-time Monitoring of Ligand-receptor Interactions with Fluorescence Resonance Energy Transfer
12:23

Real-time Monitoring of Ligand-receptor Interactions with Fluorescence Resonance Energy Transfer

Published on: August 20, 2012

Biosensor-based evaluation of liposomal binding behavior.

Gerd Bendas1

  • 1Department of Pharmacy, Rheinische Friedrich Wilhelms University Bonn, Germany.

Methods in Molecular Biology (Clifton, N.J.)
|December 17, 2009
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fully Synthetic Non-Carbohydrate Heparin Mimetics-Perspectives for Therapeutic Anticoagulation and Beyond?

Archiv der Pharmazie·2026
Same author

Comparing Heparin and Heparin Mimetics in Targeting Immunomodulatory Proteins from Platelets to Activate T Cell-Dependent Immune Response in Oncology.

ACS pharmacology & translational science·2026
Same author

Increased efficacy of PARP inhibitors against cisplatin-sensitive and -resistant ovarian cancer cells mediated via ATR and ATM inhibition.

Cell death discovery·2025
Same author

Target Engagement Studies and Kinetic Live-Cell Degradation Assays Enable the Systematic Characterization of Histone Deacetylase 6 Degraders.

ACS pharmacology & translational science·2025
Same author

Development and Characterization of the First Selective Class IIb Histone Deacetylase Degraders.

Journal of medicinal chemistry·2025
Same author

A Novel Series of Synthetic Heparin-Mimetics-Itaconic Acid-Containing Copolymers for Targeting Tumor Cell Coagulability and Metastasis.

Macromolecular bioscience·2025

Biosensors using acoustic wave sensors quantify liposomal binding and appearance on surfaces. This technology aids in predicting and controlling liposome behavior for potential therapeutic applications.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Analytical Chemistry

Background:

  • Biosensors offer label-free detection of biological interactions.
  • Liposomal behavior at binding sites impacts therapeutic efficacy.
  • Acoustic wave sensors provide mass-sensitive detection.

Purpose of the Study:

  • To investigate liposomal binding behavior on simulated biological surfaces using acoustic wave sensors.
  • To quantify liposomal binding intensity and analyze liposome appearance (deformation, fusion).
  • To explore the potential of biosensors for predicting and modulating liposomal behavior.

Main Methods:

  • Utilized quartz crystal microbalance (QCM) as an acoustic wave sensor.
  • Bio-functionalized quartz sensors with avidin.

More Related Videos

Capturing the Interaction Kinetics of an Ion Channel Protein with Small Molecules by the Bio-layer Interferometry Assay
10:41

Capturing the Interaction Kinetics of an Ion Channel Protein with Small Molecules by the Bio-layer Interferometry Assay

Published on: March 7, 2018

Related Experiment Videos

Last Updated: Jun 17, 2026

Real-time Monitoring of Ligand-receptor Interactions with Fluorescence Resonance Energy Transfer
12:23

Real-time Monitoring of Ligand-receptor Interactions with Fluorescence Resonance Energy Transfer

Published on: August 20, 2012

Capturing the Interaction Kinetics of an Ion Channel Protein with Small Molecules by the Bio-layer Interferometry Assay
10:41

Capturing the Interaction Kinetics of an Ion Channel Protein with Small Molecules by the Bio-layer Interferometry Assay

Published on: March 7, 2018

  • Performed liposomal binding experiments using biotin-containing liposomes as model ligands.

    • Main Results:

    • Quantified liposomal binding intensity to avidin-modified sensors.
    • Gained insights into liposome deformation and fusion upon binding.
    • Demonstrated the influence of binding strength and lipid composition on liposomal behavior.

    Conclusions:

    • Acoustic wave biosensors are effective tools for studying liposomal-surface interactions.
    • Liposome appearance and binding behavior can be analyzed and potentially modulated.
    • This approach holds promise for optimizing liposome-based drug delivery systems.