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Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Updated: Jun 17, 2026

Robot-Assisted Kidney Transplantation

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

[AB0-incompatible kidney transplantation--case 13/2009].

Martina Guthoff¹, Dorothee Wernet, Wolfgang Steurer

¹Universitätsklinikum Tübingen, Medizinische Klinik, Abteilung für Endokrinologie, Diabetes, Nephrologie, Angiologie und Klinische Chemie.

Deutsche Medizinische Wochenschrift (1946)

|December 17, 2009

Summary

Successful blood group incompatible kidney transplants are now possible with preconditioning, expanding living donor options by 20%. This approach avoids intensified immunosuppression and ensures excellent graft function, comparable to compatible transplants.

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Area of Science:

Nephrology
Transplantation immunology
Immunosuppression protocols

Background:

Living donor kidney transplantation is limited by blood group (AB0) incompatibility.
Patients with chronic kidney disease often face challenges in finding compatible donors.

Observation:

A 49-year-old patient with blood group O and chronic kidney disease was evaluated for transplantation from a blood group A spouse.
Preconditioning with rituximab and immunoadsorption reduced recipient isoagglutinin titers to facilitate the AB0-incompatible transplant.
The transplantation proceeded without complications, and postoperative immunoadsorption was not required.

Findings:

Recipient preconditioning enables successful AB0-incompatible kidney transplantation.
This strategy increases the pool of eligible living donor kidney transplant candidates by up to 20%.
Excellent renal allograft function was maintained for 18 months post-transplant with corticosteroid-free immunosuppression.

Implications:

AB0-incompatible kidney transplantation significantly expands donor options for patients with end-stage renal disease.
Preconditioning protocols offer a viable solution for blood group-mismatched living donor kidney transplantation.
Comparable long-term allograft outcomes suggest AB0-incompatible transplantation is a safe and effective alternative.