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Updated: Jun 17, 2026
05:25
Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
Aprotinin-associated risks in off-pump coronary artery bypass grafting
H B Bittner1, M Lange, J Lemke
1Cardiovascular and Thoracic Surgery, Heart Center Leipzig, Leipzig, Germany. heartbeatgermany@aol.com
The Thoracic and Cardiovascular Surgeon
|December 17, 2009
Summary
Aprotinin, a serine protease inhibitor, showed a good safety profile in off-pump coronary artery bypass grafting (OPCABG) surgery. This study found no increased risk of mortality or complications in patients receiving aprotinin during OPCABG.
Area of Science:
- Cardiology
- Anesthesiology
- Pharmacology
Background:
- Limited data exists on the safety of aprotinin in off-pump cardiac surgery.
- Aprotinin is a serine protease inhibitor used to reduce bleeding.
Purpose of the Study:
- To assess the safety and risks of aprotinin administration in adult patients undergoing off-pump coronary artery bypass grafting (OPCABG).
Main Methods:
- Retrospective analysis of 391 patients receiving aprotinin (1 or 2 million kallikrein inhibiting units) during OPCABG.
- Comparison with 370 control patients who did not receive aprotinin.
- Exclusion of other antifibrinolytic agents in both groups.
Main Results:
- Similar preoperative characteristics, ICU, and hospital stay between aprotinin and control groups.
- Comparable frequencies of postoperative cardiac, renal, neurological, and respiratory complications, and hospital mortality.
- No significant difference in myocardial enzyme levels within 72 hours post-surgery.
Conclusions:
- Aprotinin use in OPCABG was not associated with increased hospital mortality or complications.
- Aprotinin demonstrates a good safety profile in a large OPCABG patient population.
- Aprotinin remains a viable antifibrinolytic treatment option for OPCABG.
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