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Related Experiment Video

Updated: Jun 17, 2026

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)

Published on: April 21, 2019

[Disorders with elevated immunoglobulin E levels].

Urszula Nowicka1

  • 1III Klinika Chorób Płuc Instytutu Gruźlicy i Chorób Płuc w Warszawie. unowicka@poczta.onet.pl

Pneumonologia I Alergologia Polska
|December 17, 2009
PubMed
Summary
This summary is machine-generated.

Immunoglobulin E (IgE) levels are lowest at birth, peak in adolescence, and decline with age. Elevated IgE indicates atopic conditions but also other diseases, as detailed in this review.

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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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Related Experiment Videos

Last Updated: Jun 17, 2026

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
07:10

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Published on: April 21, 2019

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Area of Science:

  • Immunology
  • Clinical Chemistry

Background:

  • Immunoglobulin E (IgE) is the least abundant circulating immunoglobulin isotype.
  • Serum IgE levels are low at birth, increase until adolescence, and decrease in older adults.

Purpose of the Study:

  • To present the broad spectrum of diseases associated with elevated serum IgE levels.
  • To highlight the clinical significance of IgE in various pathological conditions.

Main Methods:

  • Literature review of studies investigating serum IgE concentrations.
  • Analysis of conditions associated with elevated IgE levels.

Main Results:

  • Elevated serum IgE is commonly linked to atopic diseases.
  • Numerous other conditions, including infections, neoplasms, and inflammatory disorders, are also associated with increased IgE.

Conclusions:

  • Serum IgE levels exhibit dynamic changes throughout the lifespan.
  • Elevated IgE is a marker for atopic diseases and a wide range of other non-atopic disorders, necessitating comprehensive diagnostic evaluation.