Related Experiment Video
Updated: Jun 17, 2026

06:42
Measuring Phosphorus Release in Laboratory Microcosms for Water Quality Assessment
Published on: July 22, 2019
Phosphorus: the philosopher's stone discovered in 1669
Vincenzo Savica1, Domenico Santoro, Agostino Mallamace
1Department of Nephrology, University of Messina, Messina, Italy. visavica@tin.it
Journal of Nephrology
|December 17, 2009
Summary
High phosphate levels are toxic, increasing cardiovascular risk even in those without kidney disease. Understanding phosphorus history aids in recognizing its crucial role and potential dangers.
Area of Science:
- Nephrology
- Cardiovascular Science
- Biochemistry
Background:
- Phosphate's role in nephrology is increasingly recognized.
- High phosphate serum levels are linked to cardiovascular risk in chronic renal failure patients.
Observation:
- The association between high phosphate and cardiovascular risk extends beyond chronic kidney disease patients.
- Elevated phosphate levels correlate with increased cardiovascular disease risk and atherosclerosis progression in the general population.
Findings:
- Phosphate is a physiologically crucial anion.
- Understanding the history of phosphorus (discovered in 1669) provides context for its toxic effects.
Implications:
- Recognizing the detrimental effects of high phosphate levels is vital for cardiovascular health management.
- Further research into phosphorus's physiological impact is warranted.
Related Concept Videos
The Phosphorus Cycle
Unlike carbon, water, and nitrogen, phosphorus is not present in the atmosphere as a gas. Instead, most phosphorus in the ecosystem exists as compounds, such as phosphate ions (PO43-), found in soil, water, sediment and rocks. Phosphorus is often a limiting nutrient (i.e., in short supply). Consequently, phosphorus is added to most agricultural fertilizers, which can cause environmental problems related to runoff in aquatic ecosystems.
Protein Kinases and Phosphatases
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Protein Kinases and Phosphatases
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Roles of Electrolytes: Calcium and Phosphate
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily regulated...
The calcium concentration in blood plasma is primarily regulated...
Introduction to Electrolytes
In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...
Role of Sodium
One...
Phosphoinositides and PIPs
Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
