Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hedgehog Signaling Pathway

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

Hedgehog Signaling Pathway

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

Endocrine Signaling

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.

Endocrine Signaling

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.

Structures of the Endocrine System

Structures of the Endocrine System

The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...

Chemical Signaling in the Endocrine System

Chemical Signaling in the Endocrine System

A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The extraordinary career of Professor Dr. Simon van Creveld.

American journal of medical genetics. Part A·2014

Same author

Giovanni Neri.

American journal of medical genetics. Part A·2013

Same author

Perspectives on RAGE signaling and its role in cardiovascular disease.

American journal of medical genetics. Part A·2013

Same author

The AKT genes and their roles in various disorders.

American journal of medical genetics. Part A·2013

Same author

Proteus syndrome review: molecular, clinical, and pathologic features.

Clinical genetics·2013

Same author

Ellis-van Creveld syndrome: its history.

Pediatric radiology·2013

Same journal

How does Léri-Weill Dyschondrosteosis Affect Adults' Health-Related Quality of Life? - A Norwegian Cross-Sectional Study Exploring the Physical and Mental Burden.

American journal of medical genetics. Part A·2026

Same journal

Re-Identification of the Panamanian Guna/Kuna/Cuna OCA2 Founder Association Through Two American-Born Siblings.

American journal of medical genetics. Part A·2026

Same journal

Biallelic Variant in HAPLN1 is Associated With Skeletal Dysplasia With or Without Congenital Heart Disease.

American journal of medical genetics. Part A·2026

Same journal

MYH11-Related Hereditary Type 2 Visceral Myopathy in a Large Kindred: Diagnostic Odyssey With Milder Clinical Manifestations.

American journal of medical genetics. Part A·2026

Same journal

Positron Emission Tomography (PET) in Phenylketonuria: A Systematic Review of Brain Metabolism Beyond Phenylalanine.

American journal of medical genetics. Part A·2026

Same journal

Re: "Clinical Insights From a Case of Sifrim-Hitz-Weiss Syndrome With a CHD4 Variant: Expanding the Phenotypic Spectrum and Its Response to Growth Hormone Therapy".

American journal of medical genetics. Part A·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 17, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

Hedgehog signaling: endocrine gland development and function.

M Michael Cohen¹

¹Department of Pediatrics, Faculty of Medicine, Dalhousie University, 5981 University Avenue, Halifax, Nova Scotia, Canada B3H 1W2. mmichael.cohenjr@gmail.com

American Journal of Medical Genetics. Part A

|December 17, 2009

Summary

This summary is machine-generated.

Hedgehog signaling

More Related Videos

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland

Published on: December 1, 2015

Evaluation of Mammary Gland Development and Function in Mouse Models

Evaluation of Mammary Gland Development and Function in Mouse Models

Published on: July 21, 2011

Related Experiment Videos

Last Updated: Jun 17, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland

Published on: December 1, 2015

Evaluation of Mammary Gland Development and Function in Mouse Models

Evaluation of Mammary Gland Development and Function in Mouse Models

Published on: July 21, 2011

Area of Science:

Developmental Biology
Endocrinology
Genetics

Background:

Hedgehog signaling is crucial for embryonic development, including endocrine gland formation.
Holoprosencephaly (HPE) is a congenital disorder with significant endocrine implications.
Understanding endocrine involvement in HPE is vital for patient management.

Purpose of the Study:

To analyze the role of hedgehog signaling in the development of key endocrine glands.
To review experimental and pathological findings related to endocrine organs in HPE.
To discuss specific endocrine dysfunctions observed in holoprosencephaly.

Main Methods:

Review of experimental and pathological data on endocrine gland development.
Analysis of human and animal models of holoprosencephaly.
Compilation and review of reported endocrine function tests in HPE cases.

Main Results:

The pituitary gland is typically present in human HPE, unlike in animal models, due to differences in gene mutation.
Endocrine function tests are infrequent in HPE, often due to early mortality or masked symptoms.
Diabetes insipidus is observed in HPE, potentially linked to hypothalamic-pituitary abnormalities.

Conclusions:

Hedgehog signaling plays a significant role in endocrine gland development.
Human and animal models of HPE exhibit distinct pituitary gland characteristics.
Further investigation into endocrine dysfunction, particularly diabetes insipidus, in HPE is warranted.