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Resveratrol bioavailability and toxicity in humans
Charles-Henry Cottart1, Valérie Nivet-Antoine, Christelle Laguillier-Morizot
1APHP, Hôpital Universitaire Charles Foix, Service de Biochimie, Ivry sur Seine, France. charles-henry.cottart@parisdescartes.fr
Molecular Nutrition & Food Research
|December 17, 2009
Summary
Resveratrol, a beneficial polyphenol, is well-absorbed and tolerated in humans. This review supports its potential as a pharmacological drug, despite varied study results.
Area of Science:
- Pharmacology and Toxicology
- Nutraceuticals and Natural Products
Background:
- Resveratrol exhibits anti-inflammatory and antitumor properties.
- Human studies on resveratrol are limited and yield inconsistent results due to methodological variations.
Purpose of the Study:
- To review recent human studies on resveratrol's pharmacokinetics, bioavailability, and toxicity.
- To assess resveratrol's safety and metabolic profile for potential therapeutic use.
Main Methods:
- Systematic review of recent human clinical studies.
- Analysis of pharmacokinetic and bioavailability data.
- Evaluation of reported toxicity and tolerability.
Main Results:
- Resveratrol is readily absorbed and rapidly metabolized into sulfo and glucuronide conjugates.
- These metabolites are efficiently eliminated via urine.
- Resveratrol demonstrates good tolerability with no significant toxicity reported in human studies.
Conclusions:
- Resveratrol exhibits favorable pharmacokinetic and safety profiles in humans.
- These findings support further investigation of resveratrol as a pharmacological agent.
- The data provide a basis for designing robust human efficacy studies.
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