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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jun 17, 2026

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

Wnt modulators in the biotech pipeline.

Jean-Philippe Rey1, Debra L Ellies

  • 1OsteoGeneX Inc., Kansas City, Kansas 66160, USA.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|December 17, 2009
PubMed
Summary

This review clarifies Low-density lipoprotein receptor-related protein (LRP) co-receptor roles in Wnt signaling. It details LRP family members and highlights the cystine-knot motif

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Biochemistry

Background:

  • The Wnt signaling pathway is crucial for cellular processes.
  • Low-density lipoprotein receptor-related protein (LRP) acts as a key co-receptor in Wnt signaling.
  • Understanding LRP's function is vital for deciphering Wnt pathway regulation.

Purpose of the Study:

  • To elucidate the mechanisms of LRP co-receptor-mediated Wnt pathway signaling.
  • To categorize the LRP receptor family and its members.
  • To explore the role of the cystine-knot protein motif in LRP interactions and Wnt signaling.

Main Methods:

  • Proteomics was employed to analyze and classify the LRP receptor family.
  • Literature review and analysis of protein structures and functions.

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The Soft Agar Colony Formation Assay
08:01

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

Related Experiment Videos

Last Updated: Jun 17, 2026

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

The Soft Agar Colony Formation Assay
08:01

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

  • Discussion of specific proteins featuring the cystine-knot motif.

    • Main Results:

    • The LRP receptor family was subdivided into six sub-families, comprising twelve members.
    • Proteins with a cystine-knot motif, including Sclerostin and Norrin, were identified.
    • The cystine-knot motif's involvement in mediating Wnt signaling via LRP interactions was discussed.

    Conclusions:

    • LRP co-receptors are integral to Wnt pathway signaling.
    • The classification of LRP family members provides a framework for further research.
    • The cystine-knot motif represents a significant structural element influencing Wnt signal transduction through LRP.