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Published on: August 25, 2023
Gestational trophoblastic neoplasia, an ancient disease: new light and potential therapeutic targets
Mo'iad Alazzam1, John Tidy, Barry W Hancock
1Department of Gynaecologic Oncology, Royal Hallamshire Hospital, Sheffield, UK. m.alazzam@sheffield.ac.uk
Abstract:
Gestational trophoblastic neoplasia is a rare malignancy, which can occur after any type of pregnancy. The incidence varies according to the geographical location and ethnic origin. Although most patients with gestational trophoblastic neoplasia are cured by conventional chemotherapy and surgery, some suffer resistant disease and may die. New therapeutic agents are needed to reduce the toxicity associated with conventional chemotherapy and treat those with resistant or refractory disease. Molecular targeted treatment provides an exciting avenue, however, the biology of gestational trophoblastic neoplasia is not well understood. This review briefly summarises the recent advances in understanding the pathogenesis and molecular biology of this group of diseases and sheds light on molecules that could provide potential therapeutic targets.
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