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Aquagenic acrokeratoderma.

Di-Qing Luo¹, Yu-Kun Zhao, Wu-Jun Zhang

¹Department of Dermatology, Huangpu Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. luodq@mail.sysu.edu.cn

International Journal of Dermatology

|December 18, 2009

Summary

This summary is machine-generated.

Aquagenic acrokeratoderma (AA) affects both males and females, presenting as hand lesions after water exposure. Treatments like topical formalin and alum solution offer partial relief.

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Area of Science:

Dermatology
Rare Diseases
Clinical Case Study

Background:

Aquagenic acrokeratoderma (AA) is a rare skin condition characterized by transient lesions after water exposure.
The exact cause of AA remains unknown, with a previously suggested female predilection.

Observation:

This study analyzed four Chinese patients (2 males, 2 females) aged 14-33 with AA.
Lesions appeared as papules and plaques on hands within minutes of water contact, resolving within an hour after drying.
Symptoms were exacerbated by warm water and detergents, and in one case, involved feet with associated erythema and hyperhidrosis.

Findings:

Histopathology revealed hyperkeratosis and dilated eccrine ducts post-water exposure, with normal skin upon drying.
Warm water accelerated lesion onset compared to cold water.
Topical treatments including 3% formalin in alcohol and 3% potassium aluminium sulfate solution provided partial symptom relief without adverse effects.

Implications:

Aquagenic acrokeratoderma can affect both genders and potentially involve the feet.
Understanding triggers like water temperature and detergents can aid in management.
Topical formalin and alum solutions represent potential therapeutic options for AA.