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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment
04:00

Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment

Published on: July 26, 2024

[Frailty in the elderly].

Marianne B van Iersel1, David R M Jansen, Marcel G M Olde Rikkert

  • 1Ziekenhuis Rijnstate, Arnhem, The Netherlands. m.vaniersel@ger.umcn.nl

Nederlands Tijdschrift Voor Geneeskunde
|December 18, 2009
PubMed
Summary
This summary is machine-generated.

Frailty syndrome identifies vulnerable older adults at higher risk of decline. Recognizing its diverse criteria is key for tailored geriatric care and preventing adverse outcomes in the elderly.

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Frailty Assessment in an Aging Mouse Model
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Frailty Assessment in an Aging Mouse Model

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Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment
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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

Area of Science:

  • Gerontology
  • Geriatric Medicine
  • Public Health

Background:

  • Older adults exhibit significant variability in multimorbidity, functional status, and care needs.
  • Frailty is an emerging concept describing vulnerable older individuals prone to functional decline, institutionalization, and mortality.

Observation:

  • A case study of a 97-year-old woman exemplifies frailty, presenting with somatic multimorbidity alongside fatigue, weight loss, reduced strength, mood changes, fear of falling, and slowed gait velocity.
  • These symptoms lacked a clear attributable disease, underscoring the utility of the frailty concept.

Findings:

  • The application of the frailty syndrome is expanding in clinical practice.
  • Frailty emphasizes the necessity of individualized treatment guidelines and integrated care for older adults.
  • Preventing adverse outcomes requires selecting healthcare interventions appropriate for frail elderly individuals.

Implications:

  • The clinical application of frailty is growing, highlighting the need for personalized geriatric care.
  • Diverse criteria for defining frailty exist, posing challenges for a universal definition.
  • Understanding the benefits and limitations of the frailty concept is crucial for effective clinical use in elder care.