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The Cochlea01:13

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
Anatomy of the Ear01:16

Anatomy of the Ear

Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
The Auditory Ossicles01:11

The Auditory Ossicles

The auditory ossicles of the middle ear transmit sounds from the air as vibrations to the fluid-filled cochlea. The auditory ossicles consist of two malleus (hammer) bones, two incus (anvil) bones, and two stapes (stirrups), one on each side. These bones develop during the fetal stage and are the ones to ossify first. They are fully mature at birth and do not grow afterward.
The aptly named stapes look very much like a stirrup. The three ossicles are unique to mammals, and each plays a role in...
Urodynamic Studies: Uroflowmetry01:19

Urodynamic Studies: Uroflowmetry

Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...

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Related Experiment Video

Updated: Jun 17, 2026

Enhanced Cochlear Coverage and Hearing Preservation in High-Frequency Hearing Loss via Electric Acoustic Stimulation with Longer Electrode
03:49

Enhanced Cochlear Coverage and Hearing Preservation in High-Frequency Hearing Loss via Electric Acoustic Stimulation with Longer Electrode

Published on: October 11, 2024

Cochlear dysfunction in hyperuricemia: otoacoustic emission analysis.

Sherifa A Hamed1, Amal M El-Attar

  • 1Department of Neurology, Assiut University Hospital, Assiut, Egypt. hamed_sherifa@yahoo.com

American Journal of Otolaryngology
|December 18, 2009
PubMed
Summary

Primary hyperuricemia is linked to subclinical cochlear dysfunction, affecting hearing at higher frequencies. This study highlights the potential for early detection using otoacoustic emissions in patients with high uric acid levels.

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Area of Science:

  • Otoacoustic Emissions
  • Audiology
  • Metabolic Disorders

Background:

  • Primary hyperuricemia is a metabolic condition.
  • Metabolic diseases can impact cell metabolism and function.
  • Potential link between hyperuricemia and cochlear dysfunction needs investigation.

Purpose of the Study:

  • To provide evidence associating primary hyperuricemia with cochlear dysfunction.
  • To explore hyperuricemia's role in cochlear dysfunction similar to other metabolic diseases.
  • To investigate the link between metabolic health and auditory function.

Main Methods:

  • Evaluated cochlear function in 25 asymptomatic hyperuricemia subjects.
  • Utilized diagnostic audiometry, transient evoked otoacoustic emissions (TEOAE), and distortion product otoacoustic emissions (DPOAE).
  • Assessed vascular health via common carotid artery intima-media thickness and intracranial vessel flow velocity.

Main Results:

  • Reduced TEOAE and DPOAE responses at higher frequencies were observed in hyperuricemia subjects.
  • Abnormalities correlated with uric acid levels, age, hyperuricemia duration, and vascular measures.
  • Multivariate analysis confirmed correlation between high-frequency hearing changes and hyperuricemia severity/duration.

Conclusions:

  • Subclinical cochlear function changes are associated with primary hyperuricemia.
  • Otoacoustic emissions are useful for early cochlear dysfunction detection.
  • Hyperuricemia may compromise outer hair cell function and blood supply, impairing hearing.