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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Sinonasal teratocarcinosarcoma.

Yan-Ye Su¹, Michael Friedman, Chun-Chen Huang

¹Department of Otolaryngology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

American Journal of Otolaryngology

|December 18, 2009

Summary

This summary is machine-generated.

Sinonasal teratocarcinosarcoma (SNTCS) is rare. Aggressive treatment, including early neck dissection, may reduce metastasis risk in SNTCS patients.

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Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

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Published on: July 5, 2021

Area of Science:

Oncology
Head and Neck Surgery

Background:

Sinonasal teratocarcinosarcoma (SNTCS) is a rare, aggressive neoplasm originating in the nasal cavities and paranasal sinuses.
Fewer than 50 cases are documented, with local recurrence being the primary treatment failure cause.

Observation:

A 52-year-old male presented with SNTCS in the left sinonasal cavity.
Recurrent cervical metastasis occurred over 28 months despite surgery and radiotherapy.
The patient ultimately died of lung metastasis 43 months post-surgery.

Findings:

This case involved a younger patient than typically reported for SNTCS.
Simultaneous good locoregional control and distant lung metastasis are unusual findings.
Metastasis to lower cervical lymph nodes and distant sites is seldom described.

Implications:

Early and aggressive elective neck dissection is recommended for SNTCS.
Careful examination of surrounding soft tissues for lymphadenopathy is crucial.
These measures may lower the risk of cervical or distant metastasis in SNTCS.