Related Experiment Video
Updated: Jun 17, 2026

Automation of Bio-Atomic Force Microscope Measurements on Hundreds of C. albicans Cells
Published on: April 2, 2021
Caspofungin-non-susceptible Candida isolates in cancer patients
Diamantis P Kofteridis1, Russell E Lewis, Dimitrios P Kontoyiannis
1Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. dkontoyi@mdanderson.org
Objectives:
To identify the frequency of caspofungin-non-susceptible Candida isolates in cancer patients with candidiasis.
Methods:
We reviewed the in vitro susceptibilities (M27-A3 CLSI method) of 650 Candida spp. associated with invasive candidiasis episodes in 582 hospitalized cancer patients (2005-08).
Results And Conclusions:
We identified seven caspofungin-non-susceptible Candida strains (three Candida tropicalis, two Candida glabrata and two Candida albicans) from 650 Candida isolates (1%). C. tropicalis (three out of seven) was the most common non-susceptible species isolated. All patients responded to a change of antifungal therapy. Further surveillance should focus on the potential broader emergence of echinocandin resistance, as the clinical use of this antifungal class continues to expand in cancer patients.
Related Concept Videos
Cryptococcal Meningitis
Antifungal Agents
Candidiasis
Treatment Resistent Cancers
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Treatment Resistant Cancers

