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Related Experiment Videos

Autologous bone marrow transplantation.

S C Gulati1, J Yahalom, C Portlock

  • 1Memorial Sloan-Kettering Cancer Center, New York, New York.

Current Problems in Cancer
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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High-dose chemotherapy followed by autologous bone marrow transplant (AuBMT) improves survival for cancers like lymphoma and leukemia. Stem cell rescue via AuBMT offers a promising future for cancer treatment.

Area of Science:

  • Oncology
  • Hematology
  • Cancer Therapeutics

Background:

  • Dose-response relationships are observed in several malignancies.
  • Hematopoietic toxicity from dose escalation can be mitigated by bone marrow transplantation.
  • High-dose chemotherapy (high dose CT) followed by autologous bone marrow transplant (AuBMT) can lead to prolonged disease-free survival in patients with lymphoma, leukemia, Hodgkin's disease, and breast cancer.

Purpose of the Study:

  • To detail the rationale for high-dose CT.
  • To describe methods of stem cell cryopreservation for AuBMT.
  • To review complications of high-dose CT and treatment outcomes for various malignancies.

Main Methods:

  • Review of clinical trials in lymphoma, leukemia, Hodgkin's disease, and breast cancer.

Related Experiment Videos

  • Emphasis on the timing of induction and high-dose CT.
  • Analysis of stem cell rescue for AuBMT using cryopreserved bone marrow (BM) and/or peripheral blood (PB).

    • Main Results:

    • Properly sequenced therapy, including high-dose CT and AuBMT, has resulted in prolonged disease-free survival.
    • AuBMT is a crucial component for stem cell rescue after high-dose CT.
    • Clinical trials have validated the importance of this therapeutic approach.

    Conclusions:

    • Autologous bone marrow transplant (AuBMT) is a valuable technique for rescuing hematopoietic function after high-dose chemotherapy.
    • Carefully designed clinical trials have demonstrated the efficacy of AuBMT.
    • AuBMT represents a promising strategy for future cancer chemotherapy.