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Levees of immunological tolerance

Diane Mathis1, Christophe Benoist

  • 1Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.

Nature Immunology
|December 18, 2009
PubMed

Immunological tolerance guards against spurious immune responses to body constituents. Tolerance encompasses a network of mechanisms: central and peripheral, cell-autonomous and cell-interactive. Our understanding of these mechanisms has improved greatly over recent years, often reflecting new insights into the processes underlying particular autoimmune diseases. Yet it is possible that important tolerance mechanisms remain to be discovered, perhaps an explanation for the so-far disappointing clinical translation to the prevention and cure of autoimmune diseases.

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