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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Epistaxis01:30

Epistaxis

Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...

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Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
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Published on: December 20, 2024

Treating rhinitis in the older population: special considerations.

Raymond G Slavin1

  • 1Department of Internal Medicine, Division of Immunobiology, Section of Allergy & Clinical Immunology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, M157, Saint Louis, MO 63104, USA. slavinrg@slu.edu

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
|December 18, 2009
PubMed
Summary

Elderly rhinitis is common due to aging nasal changes. Treatment focuses on nasal moisture, with caution for older antihistamines and decongestants, favoring safer alternatives.

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Area of Science:

  • Geriatric Medicine
  • Otolaryngology
  • Allergy and Immunology

Background:

  • Rhinitis is a frequent, often overlooked issue in older adults.
  • Age-related nasal structural changes increase susceptibility to rhinitis.
  • Elderly patients present unique challenges including polypharmacy and altered physiological functions.

Purpose of the Study:

  • To review the specific considerations for rhinitis management in the elderly.
  • To highlight age-related factors impacting rhinitis treatment efficacy and safety.
  • To recommend appropriate therapeutic strategies for geriatric rhinitis.

Main Methods:

  • Literature review of rhinitis in aging populations.
  • Analysis of age-specific physiological and pharmacological factors.
  • Categorization of rhinitis types in the elderly.

Main Results:

  • Nasal dryness is a primary concern, necessitating mucosal hydration.
  • First-generation antihistamines and decongestants require careful administration due to potential side effects.
  • Second-generation antihistamines, intra-nasal steroids, leukotriene modifiers, and iprapropium nasal spray are generally well-tolerated.

Conclusions:

  • Tailored rhinitis treatment is crucial for the elderly, considering individual health status.
  • Prioritizing nasal moisture and selecting safer medication classes improves outcomes.
  • Further research into optimized geriatric rhinitis care is warranted.