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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Skin Cancer01:30

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Related Experiment Video

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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
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Partial cancerous changes eventually developing into superficial spreading cancer over 18 months.

Y Song1, Z Wang, Q Tang

  • 1Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang, China.

Current Oncology (Toronto, Ont.)
|December 18, 2009
PubMed
Summary

This case study highlights early gastric cancer (EGC) with cancerous ulcers, suggesting ulcers may influence EGC development. Superficial spreading cancer (SSC) progression indicates potential for deep invasion and advanced gastric cancer.

Keywords:
Borrmann type ivSuperficial gastric cancercancerous ulcer

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Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
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Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia

Published on: February 16, 2024

Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Early gastric cancer (EGC) poses a significant health challenge, often progressing to advanced stages.
  • Superficial spreading cancer (SSC) is an EGC variant with a propensity for superficial dissemination along the gastric wall.
  • The co-occurrence of cancerous ulcers with EGC requires further investigation regarding its impact on disease progression.

Purpose of the Study:

  • To report a case of superficial spreading early gastric cancer (SSC-EGC) with cancerous ulcers.
  • To analyze the disease progression and treatment outcome of this specific EGC presentation.
  • To explore the potential role of cancerous ulcers in the development and progression of EGC.

Main Methods:

  • Case report detailing a patient with persistent symptoms.
  • Surgical intervention involving total gastrectomy with D2 lymph node dissection.
  • Histopathological examination to diagnose superficial spreading cancer (SSC) with iic lesions.

Main Results:

  • A patient diagnosed with superficial spreading type of early gastric cancer (EGC) accompanied by cancerous ulcers.
  • Observation of partial cancerous changes evolving into SSC over an 18-month period.
  • Successful treatment via total gastrectomy with D2 lymph node dissection.

Conclusions:

  • The co-occurrence of cancerous ulcers may be a contributing factor in the development of EGC.
  • Superficial spreading cancer (SSC) may have the potential to progress to advanced gastric cancer (e.g., Borrmann type IV) under certain conditions, possibly involving gene expression changes.
  • SSC should be recognized as an EGC variant with specific growth characteristics.