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Asthma I: Introduction

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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

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Related Experiment Video

Updated: Jun 17, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Determinants in early life for asthma development.

Hugo P S Van Bever¹

¹Department of Pediatrics, National University Singapore, Singapore, 119260, Singapore. paevbhps@nus.edu.sg

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology

|December 18, 2009

Summary

No reliable newborn screening test for bronchial asthma (BA) exists due to its complexity. Key risk factors include family history, smoking exposure, prematurity, and early allergic signs, known as the Allergic March.

Related Experiment Videos

Last Updated: Jun 17, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Area of Science:

Pediatrics
Allergology
Respiratory Medicine

Background:

Bronchial asthma (BA) is a complex respiratory condition with varied underlying mechanisms.
A definitive screening test for predicting BA development in newborns is currently unavailable.
Numerous risk factors contribute to BA, including genetic predisposition and environmental exposures.

Purpose of the Study:

To review identified risk factors for bronchial asthma (BA) in newborns.
To highlight the significance of early allergy markers and family history in BA prediction.
To underscore the need for improved newborn screening methods for BA.

Main Methods:

Literature review of studies identifying risk factors for bronchial asthma (BA).
Analysis of established risk factors such as family history, environmental exposures, and prematurity.
Examination of early indicators of allergic disease (the Allergic March).

Main Results:

Identified risk factors include positive family history of BA, passive smoking, prematurity, and early viral infections like RSV-bronchiolitis.
An atopic constitution is a major risk factor for persistent BA.
Early symptoms and markers of allergy, alongside a positive family history for allergies, are significant predictors.

Conclusions:

The complexity of BA hinders the development of a universal screening test.
Recognizing the 'Allergic March' and family history of allergies is crucial for identifying at-risk infants.
Further research is needed to develop reliable screening tools for early BA detection.