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Updated: Jun 17, 2026
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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
[Trisomy 8 in chronic lymphocytic leukemia].
1Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029 P.R. China.
Summary
Trisomy 8 is rare in chronic lymphocytic leukemia (CLL), occurring in only 1.3% of patients. Its impact on CLL prognosis remains unknown, requiring further investigation.
Area of Science:
- Hematology
- Cytogenetics
- Oncology
Context:
- Chronic lymphocytic leukemia (CLL) is a common B-cell malignancy.
- Chromosomal abnormalities play a role in CLL pathogenesis and prognosis.
- Trisomy 8 is a less common cytogenetic aberration in hematological malignancies.
Purpose:
- To determine the incidence of trisomy 8 in a cohort of CLL patients.
- To explore the potential prognostic significance of trisomy 8 in CLL.
Summary:
- A total of 151 CLL patients were analyzed using fluorescence in situ hybridization (FISH) and chromosome karyotype analysis.
- Trisomy 8 was detected in 2 patients (1.3%), with trisomic cell counts of 8% and 10%.
- The observed karyotypes were 47,XY,+8[2]/49,XY,+14,+20,+21[2]/46,XY[16] and 47,XX,+8[2]/46,XX[18].
- This study indicates that trisomy 8 is a rare finding in CLL.
Impact:
- This study establishes a baseline incidence for trisomy 8 in CLL.
- The findings highlight the need for further research to elucidate the prognostic implications of trisomy 8 in CLL.
- Contributes to a better understanding of the cytogenetic landscape of CLL.
