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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

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Related Experiment Video

Updated: Jun 17, 2026

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
09:00

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

Published on: March 27, 2018

Renal cell therapy and beyond.

Joon Ho Song1, H David Humes

  • 1Department of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.

Seminars in Dialysis
|December 19, 2009
PubMed
Summary
This summary is machine-generated.

New renal replacement therapies, including a renal tubule cell assist device (RAD) and a selective cytopheretic inhibitory device, offer improved treatment for kidney failure by restoring cellular functions and managing inflammation.

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Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development
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Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
09:00

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

Published on: March 27, 2018

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development
09:43

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development

Published on: August 10, 2015

Area of Science:

  • Nephrology
  • Biomedical Engineering
  • Immunology

Background:

  • Current dialysis effectively clears solutes and water but lacks the metabolic, endocrine, and inflammatory regulatory functions of native kidneys.
  • Loss of renal tubule cell function contributes to systemic inflammation, increasing risks of systemic inflammatory response syndrome (SIRS), multiorgan dysfunction, and mortality in acute kidney injury (AKI) and end-stage renal disease (ESRD).

Purpose of the Study:

  • To introduce and evaluate novel renal replacement therapies designed to address the limitations of conventional dialysis.
  • To integrate renal tubule cell functions and modulate inflammatory responses in patients with acute and chronic kidney disorders.

Main Methods:

  • Development and testing of a renal tubule cell assist device (RAD) using animal or human renal tubule cells.
  • Development and preliminary study of a selective cytopheretic inhibitory device to bind and inhibit circulating leukocytes.
  • In vitro experiments, large animal studies, and FDA-approved human trials were conducted.

Main Results:

  • The RAD demonstrated viability and functionality in preclinical studies and showed clinical therapeutic benefits in human trials.
  • The selective cytopheretic inhibitory device showed promise in reducing microvascular damage by inhibiting leukocytes, mimicking immunomodulation.
  • Both devices exhibited comparable efficiency in preliminary studies.

Conclusions:

  • The RAD and selective cytopheretic inhibitory device represent promising advancements in renal replacement therapy.
  • These novel devices aim to provide comprehensive treatment by restoring full renal function and correcting inflammatory imbalances in patients with kidney disease.