Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this measurement...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determination of micro/nanoplastics on the surface of polystyrene lunch boxes by pyrolysis-gas chromatography/mass spectrometry combined with efficient magnetic capture by Fe<sub>3</sub>O<sub>4</sub> nanoparticles.

Food chemistry·2026
Same author

Mineralocorticoid receptor antagonists in dialysis patients after ACHIEVE and ALCHEMIST: updated systematic review and meta-analysis of 14 randomized trials.

Renal failure·2026
Same author

Preparation of ZIF-8 grafted magnetic solid-phase extraction sorbent for sensitive determination of four cannabinoids in urine and oral fluid.

Analytica chimica acta·2026
Same author

Albumin dialysis modeling predicts the impact of polysulfone dialyzers and flow rate on cholic acid and indoxyl sulfate removal.

The International journal of artificial organs·2026
Same author

Bovine Serum Albumin Dialysis Removes Protein-Bound Toxins from Human Serum Albumin Solution: Theory and Benchtop Validation.

Blood purification·2026
Same author

Metabolomic profiling reveals ADB-BUTINACA-induced long-term hepatotoxicity.

Chemico-biological interactions·2025

Related Experiment Video

Updated: Jun 17, 2026

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

Blood-membrane interactions during dialysis.

Zhongping Huang1, Dayong Gao, Jeffrey J Letteri

  • 1Department of Mechanical Engineering, Widener University, Chester, Pennsylvania, USA.

Seminars in Dialysis
|December 19, 2009
PubMed
Summary
This summary is machine-generated.

Blood-membrane interactions significantly impact hemodialysis by affecting solute removal. Understanding boundary layers and protein adsorption is crucial for optimizing dialysis therapies.

Related Experiment Videos

Last Updated: Jun 17, 2026

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

Area of Science:

  • Nephrology
  • Biomaterials Science
  • Biomedical Engineering

Background:

  • The dialyzer membrane is a critical component in renal replacement therapies, acting as the primary site for solute removal.
  • Blood exposure to artificial dialyzer surfaces triggers physiological responses, including coagulation and complement activation.
  • Protein adsorption onto the membrane surface is a common consequence of blood-membrane interactions.

Purpose of the Study:

  • To review how blood-membrane interactions influence solute removal in hemodialysis and related therapies.
  • To discuss the impact of secondary membrane formation and concentration polarization on solute removal.
  • To highlight protein adsorption as a removal mechanism for low-molecular-weight proteins.

Main Methods:

  • Literature review focusing on blood-membrane interactions in extracorporeal renal replacement therapies.
  • Analysis of engineering principles related to fluid flow and boundary layer formation.
  • Examination of protein adsorption phenomena and its effect on membrane performance.

Main Results:

  • Fluid flow dynamics create boundary layers that can impede solute removal.
  • Secondary membrane formation and concentration polarization significantly affect solute transport across the dialyzer membrane.
  • Protein adsorption is identified as a key removal mechanism for low-molecular-weight proteins, particularly with highly permeable synthetic membranes.

Conclusions:

  • Blood-membrane interactions profoundly influence the efficiency of solute removal during dialysis.
  • Understanding these interactions is essential for optimizing dialyzer design and dialysis procedure effectiveness.
  • Further research into managing protein adsorption can enhance the performance of synthetic membranes in hemodialysis.