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Updated: Jun 17, 2026
09:05
A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells
Published on: August 7, 2017
Cellular therapy of kidney diseases
Naohiko Imai1, Tarundeep Kaur, Mark E Rosenberg
1Division of Renal Diseases and Hypertension, Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Seminars in Dialysis
|December 19, 2009
Summary
Kidney regeneration primarily involves intrinsic cells, with mesenchymal stem cells (MSC) offering promising therapeutic potential via paracrine mechanisms for kidney diseases like acute kidney injury (AKI). Future advancements in stem cell biology will enhance cell-based therapies for kidney repair.
Area of Science:
- Nephrology
- Regenerative Medicine
- Stem Cell Biology
Background:
- Kidney regeneration understanding has shifted towards intrinsic cellular sources.
- Exogenous stem cell administration primarily acts through noncellular paracrine mechanisms.
- Mesenchymal stem cells (MSC) are highly promising for treating kidney diseases.
Purpose of the Study:
- To review the current understanding of cellular sources in kidney regeneration.
- To highlight the potential of mesenchymal stem cells (MSC) in treating kidney diseases, particularly acute kidney injury (AKI).
- To discuss future directions in stem cell-based therapies for kidney repair.
Main Methods:
- Review of recent scientific literature on kidney regeneration and stem cell therapy.
- Analysis of the mechanisms underlying stem cell-mediated kidney repair.
- Discussion of ongoing and future clinical applications of stem cell therapies for kidney diseases.
Main Results:
- Kidney regeneration is predominantly driven by intrinsic renal cells.
- Mesenchymal stem cells (MSC) exert therapeutic effects mainly through paracrine signaling.
- A clinical trial is evaluating MSC for acute kidney injury (AKI), with results anticipated soon.
Conclusions:
- Understanding MSC-secreted molecules can lead to new AKI therapies.
- Identifying adult stem cell markers will advance disease pathophysiology knowledge and cellular therapies.
- Cell-based therapies for chronic kidney disease are evolving and hold future promise for kidney repair.
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