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Related Experiment Video

Updated: Jun 17, 2026

Temperature-programmed Deoxygenation of Acetic Acid on Molybdenum Carbide Catalysts

Temperature-programmed Deoxygenation of Acetic Acid on Molybdenum Carbide Catalysts

Published on: February 7, 2017

Death by acid rain: VAP or EXIT?

Kentigern Thorburn¹, Andrew Darbyshire

¹Department of Paediatric Intensive Care, Royal Liverpool Children's Hospital - Alder Hey, Liverpool, L12 2AP, UK. kent.thorburn@alderhey.nhs.uk

Critical Care (London, England)

|December 19, 2009

Summary

Ventilator-associated pneumonia (VAP) is a hospital-acquired infection in ventilated patients. Its causes are complex, and while gastro-oesophageal reflux is common, its role in VAP is unclear.

Area of Science:

Critical care medicine
Infectious diseases
Respiratory medicine

Background:

Ventilator-associated pneumonia (VAP) is a nosocomial lower respiratory infection in mechanically ventilated patients.
Diagnosis lacks a gold standard; pathogenesis is iatrogenic and multifactorial.
Gastro-oesophageal reflux is frequent in ventilated children, but its contribution to VAP is speculative.

Discussion:

VAP significantly increases mortality, morbidity, and healthcare costs.
It leads to prolonged mechanical ventilation and hospital stays.
VAP management strategies, such as 'bundles,' are widely promoted.

Key Insights:

Understanding VAP's multifactorial pathogenesis is crucial for effective prevention and treatment.
Further research is needed to clarify the role of gastro-oesophageal reflux in VAP development.

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Standardized diagnostic criteria for VAP are essential.

Outlook:

Development of improved diagnostic tools for VAP.
Investigating novel therapeutic strategies targeting VAP pathogenesis.
Evaluating the long-term impact of VAP on patient outcomes.