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Reduced serum vaspin concentrations in obese children following short-term intensive lifestyle modification

Mi Kyung Lee1, Yoonsuk Jekal, Jee-Aee Im

  • 1Department of Sport and Leisure Studies, Yonsei University, Seoul, Republic of Korea.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 19, 2009
PubMed

Insights

Visceral adipose tissue-derived serpin (vaspin) predicts insulin resistance in obese children. Intensive lifestyle changes significantly lowered vaspin levels and improved metabolic markers.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Syndrome Research
  • Adipokine Signaling Pathways

Background:

  • Visceral adipose tissue-derived serpin (vaspin) is an adipokine with potential insulin-sensitizing properties.
  • Factors influencing circulating vaspin levels and its role in pediatric obesity remain incompletely understood.

Purpose of the Study:

  • To investigate the association between adiposity, insulin resistance, lipid profiles, and inflammatory markers, including vaspin levels, in overweight/obese children.
  • To evaluate the impact of short-term intensive lifestyle modification on circulating vaspin levels in this population.

Main Methods:

  • Cross-sectional analysis of 50 overweight/obese children (aged 11-13 years) to assess correlations between adiposity, metabolic markers, and vaspin.
  • A seven-day intensive lifestyle intervention involving diet, physical activity, and behavioral modification.

Main Results:

  • Serum vaspin negatively correlated with fasting insulin and HOMA-IR, independent of body fat percentage.
  • Short-term lifestyle modification significantly reduced vaspin levels by 39.28% (p<0.001) and increased adiponectin by 11.2% (p<0.01).
  • The intervention also led to significant improvements in HOMA-IR and lipid profiles.

Conclusions:

  • Serum vaspin is a predictor of insulin resistance in overweight and obese children.
  • Intensive, short-term lifestyle modification effectively reduces vaspin levels and ameliorates insulin resistance and dyslipidemia.
Abstract

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