Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of extended reality head-mounted displays in US health care education: a scoping review.

Frontiers in medicine·2026
Same author

Hippocampal conditioning code dominates and disrupts the place code.

bioRxiv : the preprint server for biology·2026
Same author

Closed-loop control of theta oscillations enhances human hippocampal network connectivity.

Nature communications·2025
Same author

A universal hippocampal memory code across animals and environments.

bioRxiv : the preprint server for biology·2024
Same author

Alzheimer's-linked axonal changes accompany elevated antidromic action potential failure rate in aged mice.

Brain research·2024
Same author

Editorial: The use of extended realities providing better patient outcomes in healthcare.

Frontiers in medicine·2024

Related Experiment Video

Updated: Jun 17, 2026

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
19:57

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

Published on: August 5, 2017

Age-related deficits in a forebrain-dependent task, trace-eyeblink conditioning.

Roberto Galvez1, Sabrina Cua, John F Disterhoft

  • 1Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. rgalvez@illinois.edu

Neurobiology of Aging
|December 19, 2009
PubMed
Summary

Trace-eyeblink conditioning reveals age-related neocortical plasticity decline. Older mice show impaired learning and lack normal brain changes, suggesting neocortical storage issues in aging.

More Related Videos

Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice
10:14

Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice

Published on: March 30, 2016

Classical Short-Delay Eyeblink Conditioning in One-Year-Old Children
07:36

Classical Short-Delay Eyeblink Conditioning in One-Year-Old Children

Published on: September 1, 2018

Related Experiment Videos

Last Updated: Jun 17, 2026

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
19:57

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

Published on: August 5, 2017

Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice
10:14

Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice

Published on: March 30, 2016

Classical Short-Delay Eyeblink Conditioning in One-Year-Old Children
07:36

Classical Short-Delay Eyeblink Conditioning in One-Year-Old Children

Published on: September 1, 2018

Area of Science:

  • Neuroscience
  • Cognitive Aging
  • Learning and Memory

Background:

  • Trace-eyeblink conditioning is a forebrain-dependent learning paradigm.
  • The hippocampus is crucial for learning, but the neocortex is key for long-term memory storage.
  • Neocortical plasticity may decline with age, impacting memory consolidation.

Purpose of the Study:

  • To investigate age-related behavioral and neocortical changes using trace- and delay-eyeblink conditioning in mice.
  • To determine the effectiveness of whisker versus auditory stimulation in revealing age-related learning deficits.
  • To examine neocortical plasticity, specifically barrel expansion, in relation to age and learning paradigm.

Main Methods:

  • Mice were trained using trace- and delay-eyeblink conditioning paradigms.
  • Conditioned stimuli included whisker or auditory stimulation.
  • Neocortical barrel expansion was assessed in conditioned mice.

Main Results:

  • Whisker stimulation proved more effective for revealing age-related behavioral abnormalities in C57 mice.
  • Neocortical barrel expansion, seen in trace-conditioned adults, did not occur in delay-conditioned mice or in older mice unable to learn.
  • Older mice demonstrated deficits in trace-eyeblink conditioning.

Conclusions:

  • Age-related declines in neocortical plasticity may impair long-term memory storage.
  • These neocortical abnormalities could underlie age-dependent decreases in associative learning.
  • Trace-eyeblink conditioning is a valuable tool for studying cognitive aging and neocortical function.