Commentary: update on animal models for NTP studies
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Updated: Jun 17, 2026
Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform
Published on: November 28, 2018
Angela P King-Herbert1, Robert C Sills, John R Bucher
1Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences/National Toxicology Program (NIEHS/NTP), Research Triangle Park, NC 27709, USA. Kingher1@niehs.nih.go
Abstract:
Based on recommendations of participants at the National Toxicology Program (NTP) workshop "Animal Models for the NTP Cancer Bioassay: Strains and Stocks-Should We Switch?" some modifications to the NTP rodent cancer bioassay were made. The B6C3F1 remains the mouse model used in the cancer bioassay. The use of multiple strains of mice will be explored through a new branch within the NTP, the Host Susceptibility Branch. Several rat models were evaluated; the Harlan Sprague Dawley rat is currently being used in the NTP studies.
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