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Commentary: update on animal models for NTP studies.

Angela P King-Herbert1, Robert C Sills, John R Bucher

  • 1Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences/National Toxicology Program (NIEHS/NTP), Research Triangle Park, NC 27709, USA. Kingher1@niehs.nih.go

Toxicologic Pathology
|December 19, 2009
PubMed
Summary
This summary is machine-generated.

The National Toxicology Program (NTP) updated its rodent cancer bioassay models based on expert recommendations. The B6C3F1 mouse strain continues to be used, while the Harlan Sprague Dawley rat is now the standard model for NTP studies.

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Area of Science:

  • Toxicology
  • Animal Models
  • Carcinogenesis

Background:

  • The National Toxicology Program (NTP) relies on rodent cancer bioassays to assess chemical carcinogenicity.
  • Previous workshops identified the need to evaluate and potentially update the animal models used in these critical studies.

Purpose of the Study:

  • To implement recommendations from the NTP workshop on animal models for cancer bioassays.
  • To inform decisions regarding the selection of appropriate rodent strains for carcinogenicity testing.

Main Methods:

  • Review and incorporation of participant recommendations from the "Animal Models for the NTP Cancer Bioassay: Strains and Stocks-Should We Switch?" workshop.
  • Evaluation of various rat models for suitability in NTP studies.

Main Results:

  • The B6C3F1 mouse strain remains the selected model for the NTP cancer bioassay.
  • The Harlan Sprague Dawley rat has been adopted as the current rat model for NTP studies.
  • A new Host Susceptibility Branch will explore the use of multiple mouse strains.

Conclusions:

  • The NTP has modified its rodent cancer bioassay animal models.
  • Continued use of the B6C3F1 mouse and adoption of the Harlan Sprague Dawley rat represent key changes.
  • Future research will investigate the utility of diverse mouse strains to enhance carcinogenicity assessments.