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Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
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Related Experiment Video

Updated: Jun 17, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
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Published on: July 5, 2017

Antioxidant supplementation does not alter endurance training adaptation.

Christina Yfanti1, Thorbjörn Akerström, Søren Nielsen

  • 1Center of Inflammation and Metabolism at Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. christinayfanti@inflammation-metabolism.dk

Medicine and Science in Sports and Exercise
|December 19, 2009
PubMed
Summary

Antioxidant supplementation with vitamins C and E did not enhance endurance training adaptations in healthy individuals. This study found no significant differences in exercise performance or physiological markers between supplemented and placebo groups.

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Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
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Last Updated: Jun 17, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
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Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
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Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

Area of Science:

  • Exercise Physiology
  • Nutritional Biochemistry
  • Sports Science

Background:

  • The sports community often uses antioxidant supplements, believing exercise-induced reactive oxygen and nitrogen species (RONS) cause cell damage.
  • However, RONS also play a role in redox-sensitive signaling, potentially promoting training adaptations.

Purpose of the Study:

  • To investigate the impact of combined vitamin C and E supplementation on exercise performance metrics following endurance training.
  • To assess the effects on physiological and metabolic adaptations in healthy, moderately trained individuals.

Main Methods:

  • A 12-week double-blinded, placebo-controlled study involving 21 young men undergoing supervised strenuous bicycle exercise training.
  • Participants received either combined vitamin C and E or a placebo, with muscle biopsies collected pre- and post-training.

Main Results:

  • Both groups showed significant improvements in maximal oxygen consumption, maximal power output, and lactate threshold workload after training.
  • Muscle glycogen concentration and key enzyme activities (citrate synthase, beta-hydroxyacyl-CoA dehydrogenase) also increased significantly in both groups.
  • No significant differences were observed between the vitamin-supplemented and placebo groups for any measured variable.

Conclusions:

  • Combined vitamin C and E supplementation does not appear to influence the physiological adaptations to strenuous endurance training in individuals without pre-existing vitamin deficiencies.
  • The findings suggest that antioxidant supplementation may not be beneficial for enhancing training outcomes in this population.