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Autoimmunization against the neutrophil-specific NA1 antigen is associated with HLA-DR2
J Bux1, G Mueller-Eckhardt, C Mueller-Eckhardt
1Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, F.R.G.
Abstract:
A significant association of autoimmune neutropenia (AIN) in infants due to NA1-specific autoantibodies and HLA-DR2 is reported. Nineteen of 26 infants presenting with AIN and NA1 autoantibodies possessed the DR2 antigen, while only one out of six children with AIN, but non-NA1-specific autoantibodies, was DR2 positive. Furthermore, one adult patient with primary biliary cirrhosis and periods of neutropenia due to NA1 autoantibodies also carried the DR2 antigen. All DR2-negative patients were positive for DRw6. These findings indicate that a close relationship exists between autoimmunization against the NA1 antigen and HLA-DR2 and possibly also DRw6.