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Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
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Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
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The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
Endoscopic Studies I: Bronchoscopy and Thoracoscopy01:30

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Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
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Related Experiment Video

Updated: Jun 17, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Pediatric eosinophilic esophagitis: radiologic findings with pathologic correlation.

Larry A Binkovitz1, Emily A Lorenz, Carlo Di Lorenzo

  • 1Nationwide Children's Hospital, Columbus, OH, USA. binkovitz@yahoo.com

Pediatric Radiology
|December 19, 2009
PubMed
Summary

Eosinophilic esophagitis in children often presents with normal upper gastrointestinal fluoroscopy. Radiologists should suspect this condition in patients with dysphagia or food impaction, even without clear strictures, prompting further endoscopic evaluation.

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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
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Area of Science:

  • Pediatric Gastroenterology
  • Radiology
  • Allergy Immunology

Background:

  • Eosinophilic esophagitis (EoE) is a growing cause of dysphagia and food impaction in children.
  • This condition disproportionately affects males and is frequently linked to allergies or asthma.

Purpose of the Study:

  • To correlate fluoroscopic findings of eosinophilic esophagitis with endoscopic and histologic results.
  • To assess the utility of upper gastrointestinal (UGI) imaging in diagnosing pediatric EoE.

Main Methods:

  • Retrospective review of UGI findings in 17 children diagnosed with EoE (12 boys, 5 girls).
  • Correlation of UGI results with clinical presentation, endoscopic visualization, and esophageal biopsy data.

Main Results:

  • Normal UGI findings were observed in 12 out of 17 children.
  • Five children showed strictures on UGI, with only one confirmed endoscopically.
  • Esophageal impactions and strictures in EoE may stem from dysmotility rather than fixed anatomical issues.

Conclusions:

  • Radiologists must maintain a high suspicion for EoE, as UGI findings are often normal.
  • Endoscopy and biopsy are crucial for diagnosing EoE in children with suggestive symptoms, particularly food impaction without evident esophageal strictures.