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Adult-onset Still's disease
Valentina Bagnari1, Matteo Colina, Giovanni Ciancio
1Sezione di Reumatologia, Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Ferrara, Azienda Sant'Anna, Corso della Giovecca, 203, 44100, Ferrara, Italy. valentina7@libero.it
Rheumatology International
|December 19, 2009
Summary
Adult-onset Still's disease (AOSD) is a rare systemic inflammatory condition. Diagnosis requires excluding other diseases, and treatment involves various medications, with biologics showing promise.
Area of Science:
- Rheumatology
- Immunology
- Internal Medicine
Background:
- Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder.
- Characterized by fever, rash, arthritis, and elevated inflammatory markers.
- Etiology is unknown, possibly triggered by infections in genetically susceptible individuals.
Purpose of the Study:
- To provide a comprehensive overview of Adult-onset Still's disease.
- To discuss diagnostic challenges and criteria.
- To review current and emerging therapeutic strategies.
Main Methods:
- Literature review of AOSD.
- Analysis of diagnostic criteria and laboratory findings.
- Summary of clinical course patterns and treatment outcomes.
Main Results:
- Diagnosis is clinical, requiring exclusion of other conditions.
- Elevated ESR and high serum ferritin with low glycosylated fraction are key markers.
- Three clinical patterns exist: self-limited, intermittent, and chronic articular.
Conclusions:
- AOSD diagnosis is challenging due to lack of specific tests.
- Serum ferritin levels are valuable diagnostic and activity markers.
- Corticosteroids, DMARDs, and biologics are mainstays of therapy, with biologics offering new therapeutic avenues.
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