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Related Experiment Video

Updated: Jun 17, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

Clastogenic plasma factors: a short overview.

Carita Lindholm¹, Anna Acheva, Sisko Salomaa

¹Radiation and Nuclear Safety Authority (STUK), P.O. Box 14, 00881, Helsinki, Finland. carita.lindholm@stuk.fi

Radiation and Environmental Biophysics

|December 19, 2009

Summary

Blood plasma from irradiated individuals contains factors that cause chromosome breakage. These clastogenic factors are rapidly produced, long-lasting, and linked to oxidative stress, but their health relevance requires further study.

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Area of Science:

Cytogenetics
Radiation Biology
Biochemistry

Background:

Irradiated individuals produce plasma factors with clastogenic activity, inducing chromosome aberrations.
This phenomenon is observed in various exposed populations, including atomic bomb survivors and radiotherapy patients.
These factors are detectable long after exposure and can be produced rapidly.

Purpose of the Study:

To provide a concise overview of clastogenic factors.
To discuss the occurrence, formation, and potential effectors of these factors.
To highlight the association with oxidative stress and potential candidates like TNF-alpha.

Main Methods:

Review of existing studies on clastogenic factors in plasma.
Analysis of data from irradiated subjects and other conditions associated with clastogenic plasma.
Investigation into the biochemical nature of clastogenic factors.

Main Results:

Clastogenic plasma factors are found in irradiated individuals, radiotherapy patients, and those with inflammatory diseases or genetic syndromes.
The presence of these factors is linked to oxidative stress.
Tumor necrosis factor alpha and lipid peroxidation products are suggested as potential clastogenic factors.

Conclusions:

Clastogenic factors in plasma are a widespread phenomenon associated with radiation exposure and other conditions.
Oxidative stress appears to be a common underlying mechanism.
The precise health implications and biochemical identity of these factors warrant further investigation.