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Multidetector computed tomography findings and correlations with proteinuria in nutcracker syndrome
Byoung Soo Cho1, Jin Soon Suh, Won Ho Hahn
1Department of Pediatrics, School of Medicine, Kyung-Hee University, #1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-702, Republic of Korea.
Pediatric Nephrology (Berlin, Germany)
|December 19, 2009
Summary
Multidetector computed tomography (MDCT) effectively diagnoses nutcracker syndrome (NS) in children. MDCT findings, including renal enhancement differences, correlate with proteinuria severity, aiding in assessing disease impact.
Area of Science:
- Radiology
- Pediatric Nephrology
Background:
- Nutcracker syndrome (NS) is a condition affecting renal venous drainage.
- Proteinuria is a potential complication of NS.
- Diagnostic methods for NS require further evaluation, especially in pediatric populations.
Purpose of the Study:
- To assess the diagnostic efficacy of multidetector computed tomography (MDCT) for pediatric NS.
- To investigate the association between MDCT-derived parameters and proteinuria in children with NS.
Main Methods:
- MDCT was used to measure aortic-superior mesenteric artery angle and distance.
- Renal corticomedullary enhancement differences (DCE) were analyzed.
- Sonographic parameters (PVR, APDR) and protein:creatinine ratio were assessed.
- Statistical analysis, including ROC curves, was performed to determine diagnostic accuracy.
Main Results:
- MDCT parameters (angle, distance, DCE) showed significant differences between NS patients and controls.
- DCE demonstrated high diagnostic performance (AUC 0.942), with 88.5% sensitivity and 100% specificity.
- Significant correlations were found between DCE and proteinuria (r=0.337), and distance and proteinuria (r=-0.419).
Conclusions:
- MDCT is a valuable tool for diagnosing NS in children.
- MDCT findings, particularly DCE, are significantly correlated with the degree of proteinuria.
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