Related Experiment Video

Updated: Jun 17, 2026

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue
10:28

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Published on: July 17, 2018

Adiposity is associated with endothelial activation in healthy 2-3 year-old children

Cecilia Castro1, Russell P Tracy, Richard J Deckelbaum

  • 1Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY, USA.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|December 22, 2009
PubMed

Insights

Adiposity, or excess body fat, is linked to inflammation and endothelial activation markers in healthy toddlers. This study found associations between body mass index (BMI) and specific inflammatory markers in very young children.

Area of Science:

  • Pediatric Health
  • Cardiovascular Health
  • Inflammation Research

Background:

  • Adiposity is linked to C-reactive protein in healthy children and endothelial activation in adults.
  • Data on adiposity's association with inflammation and endothelial markers in very young children are limited.

Purpose of the Study:

  • To investigate the relationship between adiposity and markers of inflammation and endothelial activation in healthy Hispanic children aged 2-3 years.

Main Methods:

  • Analysis of data from 491 healthy Hispanic children (mean age 2.7 years).
  • Measurements included body mass index (BMI), ponderal index, waist circumference, fasting insulin, insulin resistance, fasting glucose, E-selectin, and soluble vascular cell adhesion molecule (sVCAM).
  • Statistical analysis to determine associations, adjusted for age, sex, and fasting glucose.

Main Results:

  • E-selectin levels were significantly associated with BMI, ponderal index, waist circumference, fasting insulin, and insulin resistance.
  • Soluble vascular cell adhesion molecule (sVCAM) levels were associated with BMI.
  • These associations remained significant after adjusting for age, sex, and fasting glucose.

Conclusions:

  • Adiposity is associated with inflammation and endothelial activation in very early childhood.
  • Findings suggest that early childhood adiposity may contribute to subclinical inflammatory processes and vascular changes.

More Related Videos

Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting08:28

Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting

Published on: June 30, 2017

Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...