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Liposomes modified with YIGSR peptide for tumor targeting
Praveen K Dubey1, Deepak Singodia, S P Vyas
1Novel Drug Delivery Systems Laboratory, Strides Arcolab Limited, Bangalore, Karnataka, India. pd.praveen@gmail.com
Journal of Drug Targeting
|December 22, 2009
Summary
Targeted liposomes carrying chemotherapy drugs show enhanced delivery to angiogenic endothelial cells. These YIGSR peptide-anchored liposomes significantly reduced tumor growth and metastasis in preclinical models.
Area of Science:
- Nanomedicine
- Cancer Biology
- Biotechnology
Background:
- Angiogenic endothelial cells overexpress laminin receptors.
- Targeted drug delivery aims to improve cancer treatment efficacy.
- Sterically stabilized liposomes offer a promising drug carrier system.
Purpose of the Study:
- To evaluate YIGSR peptide-anchored sterically stabilized liposomes (YIGSR-SL) for targeted delivery.
- To assess the anti-cancer efficacy of YIGSR-SL loaded with 5-fluorouracil (5-FU).
- To investigate the potential of YIGSR-SL in preventing lung metastasis and angiogenesis.
Main Methods:
- In vitro endothelial cell binding assays using HUVEC.
- In vivo spontaneous lung metastasis and angiogenesis assays.
- Tumor regression studies in BALB/c mice bearing B16F10 melanoma cells.
Main Results:
- YIGSR-SL demonstrated a 7-fold higher binding affinity to HUVEC compared to non-targeted SL.
- YIGSR-SL significantly inhibited lung metastasis and angiogenesis (P
- YIGSR-SL showed significant tumor regression in a melanoma model.
Conclusions:
- YIGSR peptide anchored sterically stabilized liposomes effectively target angiogenic endothelial cells.
- YIGSR-SL loaded with 5-FU exhibit superior anti-tumor and anti-metastatic activity.
- YIGSR-SL represent a promising strategy for targeted cancer chemotherapeutics.
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