Related Experiment Video
Updated: Jun 17, 2026
Analysis of Oxidative Stress in Zebrafish Embryos
Published on: July 7, 2014
Nonylphenol Causes Decrease in Antioxidant Enzyme Activities, Increase in O(2)(-) Content, and Alteration in
Qin Xiao1, Shicui Zhang, Huarong Guo
1Department of Marine Biology, Ocean University of China, Qingdao, People's Republic of China.
Abstract:
ABSTRACT The findings in this study were that the exposure of FG cells to nonylphenol (NP) caused decreases in the cell growth rate, antioxidant enzyme activities, and ATP content; an increase in intracellular O(2)(-) content; and alteration of the organelles such as mitochondria and the RER. It is proposed that the reduction in antioxidant enzyme activities leads to accumulation of O(2)(-) content, which in turn results in the damage of mitochondrial infrastructures and a decline in energy production, which then causes the ultrastructural alterations in the cells. In addition, we show that FG cells are a good candidate system for evaluation of NP acute toxicities.
