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Human exposure to imidacloprid from dogs treated with advantage(r)
M S Craig1, R C Gupta, T D Candery
1School of Agriculture, Murray State University, 212S Oakley Applied Science Building, Murray, KY.
Toxicology Mechanisms and Methods
|December 22, 2009
Summary
Imidacloprid residue from topical flea treatment was detected in dog blood for up to 72 hours and on gloves for up to 4 weeks, indicating potential exposure risks for handlers.
Area of Science:
- Veterinary Pharmacology
- Environmental Toxicology
- Analytical Chemistry
Background:
- Topical flea control products containing imidacloprid are widely used in companion animals.
- Understanding the pharmacokinetics and residue persistence of imidacloprid is crucial for assessing potential exposure risks.
Purpose of the Study:
- To quantify transferable imidacloprid residue on gloves after petting dogs treated with Advantage(R).
- To determine imidacloprid residue levels in canine blood post-topical application.
Main Methods:
- Advantage(R) was applied to six dogs; glove and blood samples were collected at intervals up to 5 weeks.
- Residue analysis was performed using reversed-phase high-performance liquid chromatography (RP-HPLC).
Main Results:
- Peak imidacloprid residues were found in gloves (254.16 ppm) and blood (54.06 ppb) at 24 hours post-application.
- Blood residues decreased significantly by 72 hours (18.73 ppb) and were undetectable after 1 week.
- Transferable glove residues persisted for up to 4 weeks, decreasing gradually.
Conclusions:
- Imidacloprid is detectable in canine blood for up to 72 hours and transferable from the coat for up to 4 weeks.
- These findings highlight potential chronic exposure risks for individuals handling treated dogs, including veterinary professionals and pet owners.
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