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Published on: August 30, 2018
Voriconazole therapeutic drug monitoring: focus on safety
Alessandro C Pasqualotto1, Melissa O Xavier, Huander F Andreolla
1Universidade Federal do Rio Grande do Sul, Post Graduation Program in Pulmonary Sciences, Porto Alegre, Brazil.
Importance Of The Field:
Voriconazole has been widely used for the treatment of invasive fungal diseases, particularly invasive aspergillosis. Drug-drug interactions are, however, the main drawback associated with voriconazole use, since this drug suffers from extensive hepatic metabolism.
Areas Covered In This Review:
This article reviews the current literature on voriconazole therapeutic drug monitoring, with a special focus on drug safety.
What The Reader Will Gain:
An update on voriconazole metabolism, drug interactions, toxicity and the relation of these with voriconazole drug concentrations.
Take Home Message:
Therapy with voriconazole may be better guided by measuring voriconazole concentrations in the plasma.
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