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Updated: Jun 17, 2026

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
Therapy-resistant depression
1Schlosspark Clinic, Department of Psychiatry, Heubnerweg 2, D-14059 Berlin, Germany. bschor@schlosspark-klinik.de
Abstract:
Therapy-resistant depression is not untreatable. Numerous treatment methods with substantiated effectiveness exist. However, none of them are able to ensure remission. Thus, what matters when treating therapy-resistant depression is the strict, step-by-step deployment of existing therapeutic options at the right tempo and with a regular systematic evaluation of patient response. Remission should always be the aim, not just some abatement in symptoms (response). The following should be avoided: too small dosages of medication; changing the therapeutic strategy too frequently or too quickly; thoughtlessly sticking to an ineffective treatment over too long a period of time; or unsystematic poly-pharmacy. If these are all avoided than therapy-resistant depressive patients will have a good chance of recovery.
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