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Related Experiment Video

Updated: Jun 17, 2026

Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions

Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions

Published on: June 7, 2020

Sigma-1 receptor chaperones and diseases.

Shang-Yi Tsai¹, Teruo Hayashi, Tomohisa Mori

¹Cellular Pathobiology Section, Cellular Neurobiology Research Branch, IRP, NIDA, NIH, DHHS, 333 Cassell Drive, Baltimore, MD 21224, USA.

Central Nervous System Agents in Medicinal Chemistry

|December 22, 2009

Summary

The sigma-1 receptor acts as a chaperone protein, regulating calcium signaling and protecting cells from stress. Its role in diseases like cancer and addiction requires further study.

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Area of Science:

Cellular Biology
Neuroscience
Protein Biochemistry

Background:

Chaperone proteins assist in protein folding and are implicated in various diseases.
The sigma-1 receptor is a recently identified receptor chaperone.
It plays a role in cellular stress responses and signaling pathways.

Purpose of the Study:

To elucidate the function of the sigma-1 receptor as a chaperone.
To understand its role in calcium (Ca2+) signaling and cellular stress.
To explore its implications in various diseases.

Main Methods:

Investigated the sigma-1 receptor's interaction with the IP3 receptor.
Examined the sigma-1 receptor's translocation under cellular stress conditions.
Reviewed existing literature on sigma-1 receptor's involvement in diseases.

Main Results:

The sigma-1 receptor chaperones the IP3 receptor at the endoplasmic reticulum-mitochondrion interface, ensuring proper Ca2+ signaling.
Under pathological stress, it translocates to protect cells from apoptosis.
The sigma-1 receptor is crucial for metabotropic receptor signaling and cellular survival.

Conclusions:

The sigma-1 receptor is a vital receptor chaperone with essential roles in Ca2+ signaling and cellular stress response.
Its dysregulation is linked to diseases such as addiction, pain, depression, stroke, and cancer.
Further research is needed to confirm the direct contribution of its chaperone activity to these pathologies.