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Updated: Jun 17, 2026
10:13
Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
Published on: February 14, 2014
Mood, memory and movement: an age-related neurodegenerative complex?
Ann-Charlotte Granholm1, Heather Boger, Marina E Emborg
1Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA. granholm@musc.edu
Current Aging Science
|December 22, 2009
Summary
Successful aging may be achievable by addressing shared risk factors and pathways underlying age-related cognitive decline, movement disorders, and depression. Research into common mechanisms and preventive strategies is crucial for promoting brain health in later life.
Area of Science:
- Gerontology and Neuroscience
- Neurodegenerative Diseases
- Aging Research
Background:
- Age-related brain dysfunction, including depression, movement disorders, and cognitive decline, shares common underlying mechanisms.
- Identifying these shared pathways is critical for understanding and potentially mitigating age-related neurological changes.
Purpose of the Study:
- To review current theories on age-related depression, movement disorders, and cognitive impairment.
- To explore potential preventive measures for successful aging.
- To discuss the need for and development of relevant animal models.
Main Methods:
- Concept paper based on a workshop sponsored by the National Institute on Aging, American Geriatric Society, and John A. Hartford Foundation.
- Review of current literature on aging and neurodegenerative diseases.
- Synthesis of expert opinions from prominent researchers.
Main Results:
- Age-related brain dysfunction appears to share common risk factors and biological pathways.
- Several theories for depression, movement disorders, and cognitive impairment in aging were summarized.
- The importance of developing and utilizing relevant animal models was highlighted.
Conclusions:
- Addressing common underlying mechanisms may offer a path toward successful aging.
- Preventive strategies and further research, including animal models, are essential for promoting brain health.
- Interdisciplinary collaboration is key to advancing our understanding of age-related brain changes.
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