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Possible links of age related hypertension and evolution imposed features of heart and aorta

Sven Kurbel1

  • 1Department of Physiology, Osijek Medical Faculty, Osijek, Croatia. sven@jware.hr

Current Aging Science
|December 22, 2009
PubMed

Insights

Mammalian hearts need adequate diastolic aortic pressure for left ventricle perfusion due to reduced vascular density. Sufficient diastolic pressure is crucial for heart function, especially during increased heart rate and output, potentially explaining hereditary hypertension.

Area of Science:

  • Cardiovascular Physiology
  • Human Physiology
  • Cardiac Mechanics

Background:

  • Left ventricle thickness impacts heart size and strength.
  • Mammalian hearts have reduced vascular density and coronary vessel diameter.
  • Left ventricular compliance is compromised in mammals.

Purpose of the Study:

  • To explain the perfusion requirements of the left ventricle.
  • To investigate the role of diastolic aortic pressure in left ventricle perfusion.
  • To explore mechanisms contributing to age-related hypertension.

Main Methods:

  • Physiological analysis of left ventricle perfusion.
  • Examination of vascular adaptations in the mammalian heart.
  • Correlation of diastolic pressure with cardiac function.

Main Results:

  • Left ventricle perfusion is critically dependent on diastolic aortic pressure.
  • Systolic pressure causes blood vessel collapse in the left ventricle wall, especially the subendocardium.
  • Higher diastolic pressures benefit left ventricle perfusion during high heart rate and output.

Conclusions:

  • Sufficient diastolic aortic pressure is essential for optimal left ventricle perfusion.
  • The described mechanisms may contribute to the hereditary nature of age-related hypertension in humans.

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