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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

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Related Experiment Video

Updated: Jun 17, 2026

A Surgical Approach for Optic Nerve Crush in a Rabbit Model
06:15

A Surgical Approach for Optic Nerve Crush in a Rabbit Model

Published on: July 8, 2025

Standardizing optic nerve crushes with an aneurysm clip.

Dong-Fu Feng1, Er-Tao Chen, Xue-Yuan Li

  • 1Department of Neurosurgery, No. 3 People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. dffeng@21cn.com

Neurological Research
|December 22, 2009
PubMed
Summary
This summary is machine-generated.

This study standardized optic nerve crush injury using an aneurysm clip, effectively reducing retinal ganglion cells (RGCs). This method offers a reliable technique for central nervous system injury research.

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An Optic Nerve Crush Injury Murine Model to Study Retinal Ganglion Cell Survival
09:07

An Optic Nerve Crush Injury Murine Model to Study Retinal Ganglion Cell Survival

Published on: April 25, 2011

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Last Updated: Jun 17, 2026

A Surgical Approach for Optic Nerve Crush in a Rabbit Model
06:15

A Surgical Approach for Optic Nerve Crush in a Rabbit Model

Published on: July 8, 2025

An Optic Nerve Crush Injury Murine Model to Study Retinal Ganglion Cell Survival
09:07

An Optic Nerve Crush Injury Murine Model to Study Retinal Ganglion Cell Survival

Published on: April 25, 2011

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Surgical Techniques

Background:

  • Optic nerve injury models are crucial for simulating central nervous system injuries.
  • Existing protocols for optic nerve injury models lack standardization, hindering inter-study comparisons.

Purpose of the Study:

  • To establish a standardized optic nerve crush injury model in rats.
  • To evaluate the efficacy of a Yasargil aneurysm clip for creating consistent optic nerve injury.

Main Methods:

  • A Yasargil aneurysm clip was employed to induce crush injury to the rat optic nerve.
  • Histological analysis using hematoxylin-eosin staining.
  • Retinal ganglion cell (RGC) quantification via fluorescent gold dye labeling.

Main Results:

  • A significant reduction in RGC density was observed post-crush injury in the aneurysm clip group.
  • No significant difference in RGC density was found between normal and sham-operated control groups.

Conclusions:

  • The Yasargil aneurysm clip effectively creates permanent optic nerve injury.
  • This standardized technique using an aneurysm clip shows promise for optic nerve crush studies.