Related Experiment Video

Updated: Jun 17, 2026

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
06:20

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma

Published on: January 12, 2024

[Relationship between primary ocular adnexal mucosa-associated lymphoid tissue lymphoma and eye infection]

Dan-dan Zhang1, Hong-gang Liu, Hai-yan Li

  • 1Department of Pathology, Basic Medical College, Capital Medical University, Beijing 100069, China.

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|December 22, 2009
PubMed
Abstract

Insights

This study investigated common eye pathogens in Chinese patients with ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma. Results suggest these microorganisms likely play a minimal role in the development of this specific eye cancer.

Area of Science:

  • Ophthalmology
  • Infectious Disease
  • Oncology

Context:

  • Ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma is a rare malignancy.
  • The role of specific pathogens in its development remains unclear.
  • Chinese populations may have unique etiological factors.

Purpose:

  • To investigate the association between Chlamydia psittaci, Chlamydia trachomatis, Chlamydia pneumoniae, herpes simplex virus (HSV) types 1 and 2, and adenovirus types 8 and 19 with ocular adnexal MALT lymphoma.
  • To analyze the prevalence of these pathogens in archival tissue samples from Chinese patients.
  • To determine the potential role of these infectious agents in the pathogenesis of ocular adnexal MALT lymphoma.

Summary:

  • A multiplex touchdown enzyme time-release polymerase chain reaction (TETR-PCR) was used to screen 68 archival cases (38 MALT lymphoma, 3 non-MALT lymphoma, 27 chronic inflammation).
  • Chlamydia psittaci, Chlamydia trachomatis, and adenovirus type 19 DNA were not detected in any MALT lymphoma or chronic inflammation cases.
  • Chlamydia pneumoniae DNA was found in 5.3% of MALT lymphoma cases. HSV types 1 and 2, and adenovirus type 8 DNA were detected in chronic inflammation cases but not in MALT lymphoma.
  • The study found no significant association between the investigated pathogens and ocular adnexal MALT lymphoma in the studied Chinese cohort.

Impact:

  • Provides crucial etiological insights into ocular adnexal MALT lymphoma in a specific demographic.
  • Suggests that common ocular pathogens are unlikely drivers of MALT lymphoma development in Chinese patients.
  • Informs future research directions and potential diagnostic or therapeutic strategies for ocular adnexal MALT lymphoma.

More Related Videos

Induction of Ocular Surface Inflammation and Collection of Involved Tissues06:38

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Related Concept Videos

Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Accessory Structures of the Eye01:17

Accessory Structures of the Eye

Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...