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Related Experiment Video

Updated: Jun 17, 2026

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

Published on: May 9, 2021

[Efficiency of antagonist IVF cycle programming by estrogens].

A Guivarc'h-Levêque¹, P Arvis, J-L Bouchet

¹Clinique mutualiste La Sagesse, Rennes, France. anne.guivarch@wanadoo.fr

Gynecologie, Obstetrique & Fertilite

|December 22, 2009

Summary

This summary is machine-generated.

Estradiol programming in In Vitro Fertilization (IVF) with antagonists offers organizational benefits and comparable pregnancy rates to the long agonist protocol. This method is easy to implement for fertility centers.

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Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

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Last Updated: Jun 17, 2026

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

Published on: May 9, 2021

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Published on: August 11, 2023

Area of Science:

Reproductive Endocrinology
In Vitro Fertilization (IVF)

Background:

The classical long luteal agonist protocol is a standard in IVF.
Alternative protocols are sought to improve cycle organization and patient convenience.

Purpose of the Study:

To assess the efficiency of estradiol programming in antagonist In Vitro Fertilization (IVF) cycles.
To compare estradiol programming with the classical long luteal agonist protocol.

Main Methods:

A prospective randomized study compared 426 IVF cycles using estradiol antagonist protocol with 412 cycles using the long agonist protocol.
Estradiol was administered from day 25 of the previous cycle, continuing through menses until stimulation onset.
The long agonist protocol involved Decapeptyl 0.1mg starting on day 20 of the previous cycle.

Main Results:

Fewer oocytes (6.8 vs 7.6) and embryos (3.7 vs 4.1) were retrieved in the estradiol-antagonist group.
Ongoing pregnancy rates were comparable: 28.6% for estradiol antagonist vs. 27.9% for agonist.
When at least one top embryo was transferred, pregnancy rates were 37% vs. 34.8% respectively.

Conclusions:

Estradiol programming in antagonist IVF cycles facilitates center organization and is simple to implement.
This protocol appears to yield results comparable to the traditional long agonist protocol.