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Flow tracing microparticle sensors designed for enhanced X-ray contrast.

Sang Joon Lee1, Sung Yong Jung, Sungsook Ahn

  • 1Center for Biofluid and Biomimic Research, Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyojadong, Pohang 790-784, South Korea. sjlee@postech.ac.kr

Biosensors & Bioelectronics
|December 22, 2009
PubMed
Summary

Researchers developed novel X-ray contrast agents for biofluid flow tracking. Poly(vinyl alcohol) microparticles successfully encapsulated Iopamidol, showing excellent X-ray absorption for particle image velocimetry applications.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Fluid Dynamics

Background:

  • X-ray particle image velocimetry (PIV) requires effective flow tracing sensors for biofluid analysis.
  • Existing sensors may lack sufficient X-ray detectability for biological applications.

Purpose of the Study:

  • To design and fabricate X-ray detectable flow tracing sensors for biofluid flow analysis using X-ray PIV.
  • To encapsulate an X-ray contrast agent into biocompatible microparticles with controllable properties.

Main Methods:

  • Fabrication of poly(vinyl alcohol) (PVA) microparticles crosslinked with glutaraldehyde (GA) and encapsulated with Iopamidol.
  • Characterization using optical microscopy, SEM, DLS, laser Doppler electrophoresis, and NMR spectroscopy.
  • Quantification of Iopamidol using EDS and NMR; assessment of X-ray absorption using synchrotron X-ray imaging.

Main Results:

  • Successfully encapsulated Iopamidol into PVA microparticles, controlling particle size, crosslinking, swelling, and encapsulation efficiency.
  • Optimized crosslinker concentration for improved encapsulation efficiency.
  • Demonstrated excellent X-ray absorption contrast of the fabricated sensors, suitable for biological systems.

Conclusions:

  • Developed novel, biocompatible, and biodegradable PVA microparticle-based sensors for X-ray PIV.
  • The designed sensors exhibit significant X-ray absorption, making them highly applicable for biofluid flow velocimetry.