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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

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Positron Emission Tomography Imaging of Cell Trafficking: A Method of Cell Radiolabeling
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"Label and go"--a fast and easy radiolabelling method for pellets.

C Philippe1, L-K Mien, S Salar-Behzadi

  • 1Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
|December 22, 2009
PubMed
Summary
This summary is machine-generated.

Researchers developed a quick radiolabeling method using [(18)F]fluoride for pellets in fluidized bed technology. This technique enables real-time particle tracking for pharmaceutical equipment optimization.

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Area of Science:

  • Pharmaceutical Sciences
  • Chemical Engineering
  • Radiochemistry

Background:

  • Pharmaceutical equipment development requires understanding underlying processes like particle flow in fluidized beds.
  • Positron Emission Particle Tracking (PEPT) allows real-time analysis of particle motion using radiolabeled particles.

Purpose of the Study:

  • To establish a fast and simple radiolabeling technique for pellets used in fluidized bed studies.
  • To enable real-time particle motion analysis for pharmaceutical equipment optimization.

Main Methods:

  • Developed a radiolabeling technique using [(18)F]fluoride for Avicel and anion exchange resin pellets.
  • Utilized Positron Emission Particle Tracking (PEPT) to study particle motion.
  • Quantified radiotracer uptake and binding characteristics.

Main Results:

  • Achieved radiotracer uptake of 1.3%–1.7% per mg and 8.6%–16.3% per pellet.
  • Observed specific binding of [(18)F]fluoride, correlating with anion exchange resin content.
  • Demonstrated the feasibility of using [(18)F]fluoride for PEPT in fluidized bed applications.

Conclusions:

  • A rapid and effective [(18)F]fluoride labeling method for pharmaceutical pellets was established.
  • The developed technique facilitates real-time particle tracking for fluidized bed process optimization.
  • This advancement supports improved design and efficiency of pharmaceutical manufacturing equipment.