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Forkhead box M1 transcription factor: a novel target for cancer therapy

Zhiwei Wang1, Aamir Ahmad, Yiwei Li

  • 1Department of Pathology, Karmanos Cancer Institute, Wayne State University, 540 E. Canfield, Detroit, MI 48201, USA.

Cancer Treatment Reviews
|December 22, 2009
PubMed

Insights

Forkhead box M1 (FoxM1) signaling drives cancer development. Targeting FoxM1 with novel agents offers a promising therapeutic strategy for human cancers, potentially through chemoprevention.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Aberrant FoxM1 signaling is implicated in various human cancers.
  • FoxM1 plays a crucial role in cell proliferation, DNA repair, and chromosomal stability, making it a key driver of carcinogenesis.

Purpose of the Study:

  • To review the signal transduction mechanisms of FoxM1.
  • To present evidence supporting FoxM1's role in cancer development.
  • To summarize FoxM1 inhibitors, including chemopreventive agents, as potential therapeutic strategies.

Main Methods:

  • Literature review of studies on FoxM1 signaling pathways.
  • Analysis of evidence linking FoxM1 to carcinogenesis.
  • Compilation of data on FoxM1 inhibitors and their therapeutic potential.

Main Results:

  • FoxM1 signaling pathways are integral to the carcinogenic process.
  • Several inhibitors, including chemopreventive agents, demonstrate potential for FoxM1 inactivation.
  • Targeted FoxM1 inactivation shows promise for cancer prevention and treatment.

Conclusions:

  • FoxM1 is a significant therapeutic target for human cancers.
  • Development of FoxM1-targeting agents could lead to substantial therapeutic benefits.
  • FoxM1 inhibitors, particularly chemopreventive agents, offer a novel approach for cancer management.
Keywords:
FoxM1cancercell signaling pathwaychemopreventive agents

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